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Earlier SURMOUNT-1 data further reinforced these outcomes, with tirzepatide demonstrating weight loss of up to 22.5% of body weight over 72 weeks, the highest ever recorded for a pharmacological weight loss therapy at that time

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Awadallah MG, Amer GA, Fawzy RM, El-Melouk MS, Egila SS

S100A1, another calcium-binding protein, has regulated cardiac contractility and calcium-handling