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GLP-1RA corrects this imbalance through the following mechanisms: cell function protection and regeneration: GLP-1RA not only promotes insulin synthesis through cAMP-PKA pathway, but also realizes the increase of cell number and functional recovery by inhibiting cell apoptosis and promoting cell to cell transdifferentiation (for example, GCGR monoclonal antibody combined with GLP-1RA treatment can triple the number of cells in type 1 diabetes mice)

Acknowledgements This work was supported by the National Outstanding Youth Natural Science Foundation of China (82022076) and the Young Qihuang Scholar of the Tens of millions talent project of China

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The completion of a Phase I trial is a significant milestone, as its primary objective is to assess safety and tolerability in human subjects

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