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While some experts say over-the-counter diphenhydramine may have limited utility in emergencies particularly if epinephrine, the prescription-only first-line treatment for anaphylaxis, is not immediately available that utility is narrow

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The role of DHAR proteins in ascorbate regeneration has been demonstrated in tobacco, since DHAR-downregulating tobacco lines show reduced total ascorbate levels, lower dry weight, and diminished photosynthetic efficiency (Chen and Gallie, 2006