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With immunomodulatory adjuvants, also NCCIs such as NK cell cytotoxicity, (TCD 8 T cells proliferations and do TIL density), PD-L1/CTLA-4 expression will provide the opportunity to correlate biologic activity with clinical response, for targeted use (precision medicine) (232)

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Instead of giving your system a jolt, they work as precise signaling molecules that communicate with your cells, guiding your body toward optimal function