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Role of tryptophan in microbiota-induced depressive-like behavior: evidence from tryptophan depletion study

Their dual mechanismsmicrobiota regulation and barrier enhancementinclude stimulation of beneficial bacteria such as Lactobacillus and Bifidobacterium , elevation of SCFA production (e.g., butyrate as an epithelial energy source, acetate for Treg differentiation), inhibition of TLR4/NF-B inflammatory signaling, and activation of the Nrf2/HO-1 antioxidant pathway

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However, transfection of PD-related PINK1 mutants up-regulated TH and DA levels in dopaminergic neurons, making them vulnerable to oxidative stress [42]

Medications are well-studied, and the dose is established