in 1984 of leptin (45), a peripheral active appetite inhibiting hormone produced by adipocytes and acting both via specific receptor (Ob-R) on afferent vagal nerves and directly on ARC neurons enhancing satiety, raised a hope in progress in obesity therapy (44)
IF also improves the bioavailability of nitric oxide, which is an essential factor for controlling vascular tone, decreasing arterial stiffness, and preventing endothelial dysfunction [68, 73]
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