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Srivastava, S., Jiang, J., Misra, J., Seim, G., Staschke, K

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But after four months working at a research laboratory, I realized how difficult it would be to discover a new molecule that would help in treating of difficult human diseases

Induction of cell cycle arrest and DNA damage by the Hdac inhibitor panobinostat (LBH589) and the lipid peroxidation end product 4-hydroxynonenal in prostate cancer cells

When an oxidative stressor or electrophile interacts with the Keap1-Nrf2 complex, it allows for the release and subsequent nuclear accumulation of Nrf2 through a complex process of ubiquitination-inhibition, thus triggering an anti-stress response by the cell