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However, very high doses taken for extended periods may increase the risk of mild gastrointestinal symptoms

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It also works as an antagonist to opiate receptors which makes it useful in treating alcohol/opiate withdrawal syndrome

Keratinocyte-specific GPX4 knockout mice exhibit inflammatory cell infiltration and altered appendage morphology in the dermis, and the keratinocytes exhibit ferroptosis characterized by peroxidation [63]

Han H-H, Wang H-M, Jangili P, Li M, Wu L, Zang Y, et al

doi: 10.1038/s41584-023-01035-y 137 KrijbolderDIVerstappenMDijkBTVDakkakYBurgersLBoerAet al