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Mechanism of action: GLP-1 receptor agonists work through multiple physiological pathways

Differences in brain metabolite levels using MRS have been reported for autistic individuals in multiple brain regions including: the primary sensorimotor cortex SM1(He et al., 2021

This study forms the basis of future investigations into molecular mechanisms regulating feeding behaviors and metabolic processes that contribute to the weight loss effects of GLP-1R agonists

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Peer review Peer review information Nature Reviews Nephrology thanks Mark Cooper, Francesco Giorgino and the other, anonymous, reviewer(s) for their contribution to the peer review of this work