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Underlying Medical Conditions Liver disease Kidney disease Blood disorders Certain cancers 3

Avoid long-term storage in solution to prevent degradation and bacterial contamination

They act as hormones, neurotransmitters, immune messengers, and regulators of tissue repair

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However, dry powder formulations have attracted greater attention due to the dry powder particles greater drug stability and prolonged residence time in the nasal cavity compared to liquids, and also due to the potential to achieve the desired therapeutic drug levels in the brain by controlling the release rate of encapsulated drug [32]

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