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Tolerability: Adverse events mainly include mild nasal irritation in 10%-15% of subjects (example: transient congestion or mild discomfort), with no serious adverse events documented by trial sponsors and researchers

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It is analogous to the initial eGFR dip seen with ACE inhibitors or ARBs, medications widely recognized as kidney-protective despite causing a transient decline in filtration rate

Semaglutide is a prescription medication that was originally developed to help manage type 2 diabetes

GLP-1RAs for NASH GLP-1RAs have significantly improved the clinical, biochemical, and histological markers of hepatic steatosis, inflammation, and fibrosis in patients with NAFLD