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We now show that dual blockade of GDF8 and ActA can prevent muscle loss (and even result in muscle gain) during the caloric restriction and weight loss imposed by GLP-1 RA treatment, in both obese mice and NHPs

The delayed gastric emptying effect may also affect the absorption of concomitant oral medications, which is particularly important for drugs with narrow therapeutic indices

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Brief temperature excursions (under 2 hours at moderate temperatures) generally do not damage GLP-1 medications significantly