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DAA, particularly neurotoxic C3 + reactive astrocytes, can be induced by factors such as IL-1, TNF-, and C1q, released from activated neuroinflammatory microglia, as mentioned (Liddelow et al., 2017)

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Supplementary material The Supplementary Material for this article can be found online at: References 1 RostellatoRPrompJLeclercHMattaliaSFriggensNCBoichardDet al