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Estrogens play a pivotal role in the adult and developing brain (Morissette et al., 2008), exerting neuroprotective effects under homeostatic and pathologic conditions

Notably, the administration of ketone bodies, in combination with glutamine, fully restored mitochondrial respiration, suggesting a mechanistic basis for the clinical improvements observed in AGC1-deficient patients undergoing ketogenic diet therapy

FDA updates are ongoing and do not imply approval or safety

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