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doi: 10.1016/j.pupt.2010.07.002

Interventions such as the antioxidant NAC or the inhibition of MAPK8/JNK activity have been demonstrated to mitigate ROS-induced parthanatos in glioma cells [156], suggesting that MAPK8 activation contributes to parthanatos by enhancing intracellular ROS levels

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We also observed increased tissue weights for heart and kidneys in female but not male SKO mice, consistent with previously reported organomegaly in this model ( Supplementary Figures S1C, D ) Finally, blood glucose levels were examined in the non-fasted state before and after 10 days of treatment

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