the product information notes that refrigeration can cause a color change (darker yellow) which does not affect safety or effectiveness
Savage J, Waddell A
The 5mg dose offers 5 times the strength of the 1mg
In adipose tissue, inhibition of NNMT suppresses de novo lipogenesis, normalizes fat content, and improves insulin sensitivity 2-3
23, 27 Vitamin B 12 Early treatment of B 12 deficiency is particularly important because neurologic symptoms may be irreversible
[131] [132] Species from the following genera and the following individual species are known to synthesize B 12 : Propionibacterium shermanii , Pseudomonas denitrificans , Streptomyces griseus , Acetobacterium , Aerobacter , Agrobacterium , Alcaligenes , Azotobacter , Bacillus , Clostridium , Corynebacterium , Flavobacterium , Lactobacillus , Micromonospora , Mycobacterium , Nocardia , Proteus , Rhizobium , Salmonella , Serratia , Streptococcus and Xanthomonas