Other studies have identified a claudin-low (CL) subtype of TNBC, characterized by low expression of genes involved in tight junctions and epithelial cell-cell adhesion, including claudin 3, 4 and 7, E-cadherin and occludin, and exhibiting chemotherapy-resistant properties [5, 6]
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In other patients with vitamin B12 deficiency, the duration of therapy and route of administration will depend upon the cause and whether or not it is reversible
Next steps in clinical translation First-in-human safety trials (phase I) are essential: to assess dose tolerability, pharmacokinetics, biodistribution, peptide half-life, clearance, immunogenicity
