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The metabolite -KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

Replacing sodium phosphate buffer with HEPES buffer did not result in a notable change in enzyme activity, confirming that phosphate does not inhibit the activity of Cp1B (Supplementary Fig

The methods have been described in detail elsewhere [29,30,31]

[DOI] [PubMed] [Google Scholar] 21.Suchak R., Hameed O