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Oral bioavailability differs significantly from subcutaneous delivery, which means the degree of prior receptor adaptation is not directly comparable

A small increase in resting heart rate does not necessarily mean retatrutide causes serious heart problems, but heart safety is still being monitored because the medicine is investigational

Buse JB, Garg SK, Rosenstock J et al (2018) Sotagliflozin in combination with optimized insulin therapy in adults with type 1 diabetes: the North American inTandem1 study

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A greater understanding of the complex biological actions of glucagon receptor agonism will help clarify why this is a logical decision, especially when paired with GIP and GLP-1 receptor agonism