Sources: STEP 1 Trial, Wegovy prescribing information, Novo Nordisk
Cignas financial position makes cost a questionable objection
It helps stimulate insulin secretion after meals, but a significant effect observed during its use for diabetes was weight loss, leading to its application in weight management
A double-blind, randomized phase 2 study comparing various doses (1, 5, 10, 15 mg) of once weekly tirzepatide, dulaglutide (1.5 mg) and placebo, in patients with T2DM, showed tirzepatide was superior on weight loss and glucose-lowering compared to both dulaglutide and placebo [52]
N Engl J Med 392:20892099 Loomba R, Hartman ML, Lawitz EJ et al (2024) Tirzepatide for metabolic dysfunction-associated steatohepatitis with liver fibrosis
During and after tapering, your provider will monitor your weight, appetite, blood sugar, and other health markers to assess how you're doing without the full medication dose