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also called 4-aminobutyrate) is a major inhibitory neurotransmitter responsible for the regulation of presynaptic transmission in the CNS, and also in the retina

W.SuK.et al (2017)

A key mechanism affected in the "leaky" gut is called Zonulin, which helps protect the intestinal barrier

Additionally, the interaction between neurotrophic factors and the gut-brain axis is becoming increasingly relevant in the context of chronic alcohol consumption and depression