BrooksLViardotATsakmakiAStolarczykEHowardJKCaniPDet al
With tirzepatide, the active ingredient in Zepbound, people lost an average of 15% to 21% of their body weight over 72 weeks
3.3 Age-associated changes in circadian rhythms Age-associated circadian desynchrony has been shown to negatively impact metabolic function, contributing to increased oxidative stress and impaired sleep
Brian monitored his glucose levels using Dexcom CGM while adjusting to the new drug, which made him feel less hungry overall
however, no significant changes were observed in LDL or total cholesterol.28 A 2022 meta-analysis focusing on adults with metabolic syndrome risk factors reached similar conclusions, noting modest reductions in LDL cholesterol and systolic blood pressure but overall marginal changes in total cholesterol.29 A broader 2024 review summarizing human and preclinical data suggests that astaxanthin may enhance insulin sensitivity and glucose uptake while supporting lipid metabolism and antioxidant balance, though these findings are based on limited trials and changes in biomarkers.30 These effects are thought to involve activation of Nrf2, a cellular pathway that turns on the bodys own antioxidant defenses, and improved mitochondrial energy metabolism, which may help regulate oxidative stress
Acknowledgements The authors received no funding for the publication of this work
