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In contrast, the apoptosis inhibitor Z-VAD-FMK exerted only a modest effect, and the necroptosis inhibitor Necrostatin-1 showed minimal protection (Fig

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Discussion Our study provides compelling evidence that glutathione has a fundamental role in the pathogenesis of chytridiomycosis, impacting traits of both the pathogen and the host

Rotating shift work, which disrupts circadian rhythms, has also been associated with a 4% increased risk for ischemic stroke for every 5 years, with an increased risk of stroke in women with longer durations of shift work ( 15 years) (Brown et al., 2009)

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Furthermore, balancing the therapeutic window requires integrating pharmacologic co-therapies, carefully calibrated frequency-intensity matrices, and longitudinal safety surveillance, particularly in advanced cases such as castration-resistant disease