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This transporter is densely expressed in astrocytic processes abutting glutamatergic and GABAergic neurons (Boulland et al., + concentrations (Brer et al., + in astrocytes during re-accumulation of excess extracellular K + from the extracellular space after neuronal excitation (Xu et al., 2013) might therefore increase glutamine release

For patients who strongly prefer a needle-free approach, daily semaglutide or tirzepatide ODTs may be worth considering

The study is published in the journal Nature Medicine

It is knowing which patient needs a GLP-1 and which one needs a workup, how to titrate through the nausea window without losing the patient, how to protect lean mass during rapid loss, how to screen for the contraindications that matter, and how to tell a patient honestly what an adjunct will and will not do for them

Type 2 diabetes is now being seen in the young as well

But does more powerful always mean better