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10.1523/JNEUROSCI.4308-05.2006 144 Martinez-MartinP.Falup PecurariuC.OdinP.van HiltenJ

There can be tolerance with repeated use, which degrades efficacy and increases doses, leading to safety concerns

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It is located in the transmembrane helix of the MC4R gene and is known to impair cyclic-AMP, leading to severe obesity ( Table 1 Body composition, metabolic and CCM variables before and after semaglutide treatment

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