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Thomas MC, Coughlan MT, Cooper ME

Preclinical studies have indicated that GLP1RAs, such as tirzepatide, may directly impact the vasculature by enhancing endothelial function and decreasing inflammation, which are important in preventing atherosclerosis[30]

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This contrasts sharply with prescription GLP-1 agonists, which demonstrate 10-22 percent average weight loss in Phase 3 randomized controlled trials

The Rise of Oral GLP-1 Medications The introduction of Rybelsus marked a significant milestone as it became the first oral GLP-1 receptor agonist available