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(4) Finally, exploring mechanisms even more upstream, by asking what triggered the initial protein misfolding process, could get at the core of MS pathogenesis

[2] [5] NAFLD is increasingly common due to rising rates of obesity, type 2 diabetes, and metabolic syndrome

Additionally, patients should be counselled that TCAs have a delayed onset of therapeutic effect, often requiring several weeks before clinical improvement is evident

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Pregnancy, breastfeeding, severe gastrointestinal motility disorders, and a history of pancreatitis may also make these medications a poor fit

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