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M., Costa, F

Scoville SD, Freud AG, Caligiuri MA

Nature Cardiovascular Research 2025, 4: 991-1000

best for moderate-intensity steady-state cardio Evening Fasted Protocol (Alternative): Timing: At least 4-6 hours after last meal, before bed Advantages: Leverages overnight fasted period for lipolysis Considerations: Less commonly used

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Over time, skin stretches to accommodate higher weight, and with sudden fat loss, collagen and elastin fibers can struggle to provide the same snapback. Skin elasticity declines with rapid loss: Collagen and elastin break down faster than they can rebuild when fat disappears quickly, leaving skin looking looser or crepey