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Retatrutide taps into three
monotherapy doses in the Phase 2 dose-finding trial spanned 0.3 mg to 4.5 mg, with 2.4 mg used in the CagriSema combination
REDEFINE 2 (Type 2 Diabetes) In patients with T2D, CagriSema produced significant weight loss alongside glycemic improvements (HbA1c reduction), outperforming the individual components (Lingvay et al., 2025)
10.1016/j.exger.2010.07.002 Pubmed Abstract CrossRef Google Scholar View reference in article Keywords intermittent fasting, caloric restriction, cardiovascular disease, mitochondrial function, endothelial dysfunction Citation Savencu CE, Lina A, Farca G, Bn AM, Creu OM, Malia DC, Muntean DM and Sturza A (2021) Impact of Dietary Restriction Regimens on Mitochondria, Heart, and Endothelial Function: A Brief Overview
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