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HDAC inhibition synergizes with ALK inhibitors to overcome resistance in a novel ALK mutated lung adenocarcinoma model
Amyotrophic lateral sclerosis Glial contributions to ALS progression Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of motor neurons (Charcot, 1874)
In a study in the 5XFAD mouse model of AD, microbial dysbiosis was noted to be associated with activation of the endolysosomal CCAAT/enhancer-binding protein- (C/EBP-) asparagine endopeptidase (AEP) pathway (Wang et al., 2018)