The quality of these services varies significantly
In some cases, nausea, fatigue, headache, and gastric discomfort are reported
[1] CONTRAINDICATIONS History of hypersensitivity reaction to tirzepatide Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) PRECAUTIONS Kidney disease No dose adjustment is recommended in patients with any degree of renal impairment Liver disease No dose adjustment is recommended in patients with any degree of liver disease Stomach disorders Tirzepatide slows gastric emptying and is not recommended in patients with significant stomach disorders, including diabetic gastroparesis General anesthesia or deep sedation GLP-1 therapies, like tirzepatide, slow gastric emptying, possibly increasing the risk of residual gastric contents and pulmonary aspiration in patients receiving anesthesia or deep sedation for procedures
In addition, rebates are a contributing factor to rising list prices, because a manufacturer is incentivized to start negotiations with a high list price and then negotiate down to the net price so it can offer PBMs a higher rebate (but with a more profitable net price) and receive favorable formulary treatment
Heres where the GLP-1 adjustment comes in
The weight-loss benefits of GLP-1s are well documented and scientists generally know the brain regions associated with these effects
