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More serious but less common concerns apply to both classes and are described in their prescribing information, including risk of pancreatitis, gallbladder problems, and a boxed warning regarding thyroid C-cell tumors observed in rodent studies (relevance to humans is uncertain)
Clinical research over the last decades supports the use of GLP-1RAs in T2DM management (Nauck et al
Clinical trials, such as those reported by (Wilding et al
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The SUSTAIN-6 cardiovascular outcomes trial identified a statistically significant increase in diabetic retinopathy complications among semaglutide-treated patients, particularly those with pre-existing retinopathy and rapid glucose reduction