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Emerging research indicates that increased intestinal permeability can lead to the dissemination of bacteria that trigger inflammation in the bones and joints

For example, raloxifene, a selective estrogen receptor modulator used in therapy of osteoporosis, naturally has a low bioavailability and has also been shown to be extensively metabolised by UGT1A8 and UGT1A10 (Kemp et al., 2002)

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