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Various studies have been performed recently too, such as this one by the US National Library of Medicine, but there is no conclusive evidence of it working for skin lightening yet

There is evidence that central GLP1 effects could be modulated by sex steroids

These factors reinforce the need for individualized treatment plans rather than broad, unsupervised use

PMID: 264 ChenMLiYZhaiZWangHLinYChangFet al

The reported side-effect profile matches semaglutide broadly: nausea, GI upset, fatigue, and headache during titration, usually easing over the first 48 weeks

Applying inclusion and exclusion criteria for the selection of relevant articles, reaching the conclusion that the long-term use of semaglutide produces effects on body weight and modification of cardiovascular risk factors, which is associated with a reduction in the premature mortality rate and improvement of the complications associated with having an elevated body mass index