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For researchers evaluating these compounds, Dihexa offers more direct cognitive enhancement data and the practical advantage of oral bioavailability, but at the cost of greater mechanistic safety concerns and a compromised publication record

Source: The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis (2021) Methyl B12 as a syrup showed promising improvements in individuals with autism, most likely because it improved oxidative status

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Use the timelines here to set expectations, not as guarantees, and let your provider interpret your specific response

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doi: 10.1038/nrn2356, 2 AmuthavalliT