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Eur Heart J 2007;28:2915-2923

Increasing protein intake to 30% of daily calories preserves muscle mass during weight loss, maintaining a higher metabolic rate

Besides, TMAO has also been identified as a renal toxin, which leads to the progression of kidney disease

This is why many clinicians recommend treating type 2 diabetes as a chronic condition requiring ongoing management

Despite reperfusion reestablishing oxygenation, it paradoxically exacerbates the injury by promoting reactive oxygen species production and encouraging pro-inflammatory neutrophils to infiltrate the ischemic tissues, thereby amplifying the ischemic damage [49] (Fig

131 , e140766 (2021)