According to the NIH Office of Dietary Supplements, most Americans consume less than the recommended adequate intake of choline 550 mg per day for adult men and 425 mg per day for adult women
While some users report feeling more sustained energy within the first two weeks, more noticeable changes in body composition and weight often appear after about 12 weeks of consistent use
Some people benefit from weekly top-ups, while others maintain their levels with monthly visits
Homocysteine levels rise when enough Vitamin B12 antibodies are not present
For performance and wellness optimization in patients without deficiency, many benefit from injections every 2-4 weeks consistently
Lastly, vegetarians and vegans, who avoid animal products altogether, are also common candidates for B supplementation