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Researchers first isolated this sequence because of its remarkable stability in harsh digestive environments and its apparent tissue-protective properties
(24) Low stomach acid and reduced nutrients: Low stomach acid is common in hypothyroidism
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Additionally, the absence of microbiota, or the presence of broad-spectrum antibiotic-induced dysbiosis, triggered the NOD-like receptor family pyrin domain (PYD)-containing 6 (NLRP6)/Caspase 11 (Casp11) inflammasome-mediated pathway and subsequent loss of iEANs and enteric neuropathy (Muller et al., 2020a)
However, there are disputes about the relevant applicability of this evidence [18, 19], particularly considering the low survival rate of bone marrow stromal cells transplanted into the contused adult rat spinal cord [20, 21] and the need to completely fill the lesion site with neural stem cells [22]
Using sterile water beyond a single use or sharing it between patients can risk contamination, since it has no agent to suppress bacterial growth
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