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Braz J Microbiol 52:927937 Elekhnawy EA, Sonbol FI, Elbanna TE, Abdelaziz AA (2021b) Evaluation of the impact of adaptation of Klebsiella pneumoniae clinical isolates to benzalkonium chloride on biofilm formation

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113 Three meta-analyses covering 11, 12 and 13 RCTs, respectively, all found a beneficial effect of NAC in reducing the number of exacerbations by 1025%

Activation of the MAPK/ERK pathway phosphorylates the RRM2 Ser20 site, enhancing its stability and promoting drug resistance (Zhan et al., 2021)