One potential mechanism is thought to involve activation of the central nervous system, with the area postrema (AP) and nucleus of the solitary tract (NTS) and the intermediolateral nucleus (IML) of the spinal cord similarly activated by administration of GLP-1RA 29,30
Prescribing Information for Semaglutide injection
Always consult your healthcare provider before discontinuing prescribed medications
We understand the temptation especially with medication shortages and high out-of-pocket costs
In the existing study, AA caused a noteworthy rise in NF-B, IL-6, and oxidative stress levels in colon tissues that were caused by colitis
But in an IBD gut, where the mucus layer is already compromised and inflammation is already elevated, adding a mucus-consuming bacterium can exacerbate barrier damage