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Moreover, ferroptosis can propagate through intercellular mechanisms involving the release of damage-associated molecular patterns (DAMPs), dysregulation of immune checkpoints, and exosome-mediated signaling, collectively driving microglial activation, T-cell infiltration, and bloodbrain barrier disruption, culminating in systemic immune imbalance

Gd + / Gd females will have some degree of G6PD deficiency, but for clarity, we will always specify heterozygotes

Selenium works synergistically with other micronutrients, including vitamin C, vitamin E, zinc, copper, and manganese, which together play complementary roles in reducing oxidative stress and supporting immune function [40,45]

Micronutrients are critical

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