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This led to the evolution of another system of classification called mapping [18, 50, 52,53,54]

Interestingly, stroke reduction reached statistical significance only in patients with diabetes (35% reduction, relative risk 0.65), suggesting potential differences in mechanism or baseline risk profiles between diabetic and non-diabetic populations

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In the nineteen ninety, which was thirty years ago

We also discuss evolving principles of clinical trial design to evaluate drug efficacy and the emerging targets for drug development that involve either single agents or combination therapies intended to arrest or reverse disease progression