Oral semaglutide vs injectable is now a real clinical choice: Wegovy became available as a daily oral pill on January 1, 2026
In my clinical experience, tirzepatide may cause slightly less nausea or constipation, yet may have a slightly higher tendency to cause diarrhea
Compounded semaglutide is not FDA-approved for weight loss or any other use
Significant Findings and What They Mean To put it into perspective, for every 1,000 patients treated over a year, there were nine fewer cardiovascular deaths and 10 fewer cardiovascular events in those on GLP-1 medications
Due to widespread off-label use of Ozempic for weight loss, supply shortages have affected patients who require it for diabetes control, leading to NHS guidance restricting its use to licensed indications only
Additional Reported Adverse Effects Beyond gastroparesis and vision loss, patients have reported numerous other serious adverse effects that have led to FDA warning label updates as evidence accumulated