doi: 10.1016/j.molmet.2021.101402 146 AttoffKJohanssonYCediel-UlloaALundqvistJGuptaRCaimentFet al
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Most compounds can be used in impaired renal function
Peptides also face enzymatic degradation from proteases throughout the gastrointestinal tract, oxidative stress during transit, and structural challenges during absorption across the intestinal epithelium
Therefore, GIP functions as a bifunctional regulator that stabilizes blood glucose and has diverging, glucose-dependent effects on the two main pancreatic glucoregulatory hormones (Christensen et al., 2011)