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J Clin Invest (2012) 122(10):370517.10.1172/JCI61619 79 RodriguesNPBoydASFugazzaCMayGEGuoYTippingAJet alGATA-2 regulates granulocyte-macrophage progenitor cell function

The GSTs are known to be overexpressed in tumor, and naturally occurring isothiocyanates, such as benzyl isothiocyanate (BITC), are effective cancer chemopreventive compounds [95]

Its combination with gemcitabine can amplify the ICD effect of chemotherapy (Kajiwara et al., 2023), while reshaping the microenvironment (reducing M2 macrophages, recruiting NK cells) and overcoming DNA repair resistance mediated by RRM1 overexpression (such as triple-negative breast cancer models)

Carnitine can improve neurotoxicity induced by a variety of chemicals [98], and improve the imbalance of amino acid metabolism in human astrocytes and prevent ammonia-induced cytotoxicity [99]

10.1155/2015/407580 21 BaloghD

doi: 10.1371/journal.pone.0016760 363 ZhangJ.ZengW.HanY.LeeW.-R.LiouJ.JiangY