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A: The primary factor is usually the specific research objective and the model being used

References: 1 - How common is male infertility, and what are its causes

Deng, C., Tao, R., Yu, S.-Z

STING directly recruits WIPI2 to STING-positive vesicles and competes with PI3P (canonical bulk autophagy) for binding to WIPI2, adding another layer of complexity to the feedback mechanism between autophagy and cGAS-STING signaling (158) ( Figure 4 )