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Contraindications across the group commonly include pregnancy or breastfeeding and being under 18, with additional considerations such as active or recent cancer (CJC + Ipamorelin, IGF-1 LR3), active malignancy (Sermorelin), uncontrolled blood sugar disorders (CJC + Ipamorelin), uncontrolled metabolic or endocrine disorders (IGF-1 LR3, MOTS-C), severe liver or kidney disease (MOTS-C), autoimmune disorders requiring careful metabolic regulation (MOTS-C), and use of insulin or oral hypoglycaemic medications due to hypoglycaemia risk (MOTS-C)

[DOI] [PMC free article] [PubMed] [Google Scholar] 30.McGowan B.M., Bruun J.M., Capehorn M., Pedersen S.D., Pietilainen K.H., Muniraju H.A.K., Quiroga M., Varbo A., Lau D.C.W., Group S.S

This precaution may be overly conservative, but erring toward caution with minerals makes sense

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