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Additionally, as detected with a Seahorse XF analyzer, we found that the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were both decreased in ACTL6A-KD cells (Supplementary Fig 2d, e)

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Due to the conformational differences between the P72 and R72 missense mutants, we speculated that their propensity for rescue by p53 targeting drugs, such as APR-246, may differ in that mutants with the P72 SNP would exhibit increased sensitivity

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