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In women, elevated prolactin levels are thought to cause infertility by suppressing pulsatile gonadotropin releasing hormone (GnRH) release that is necessary to induce luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretion and ovulation ( Figure 2 ) ( Figure 2 Kisspeptin also exerts metabolic effects both directly via receptors in the brain, pancreas and adipose tissue and indirectly though the GnRH reproductive axis pathway ( Metabolic effects of prolactin Neurohormonal appetite regulation Prolactin plays a significant role in the neurologic regulation of appetite and satiety ( Figure 3 )

Despite a number of mechanisms have been discussed in this review, most of the ROS-induced signaling targets are yet unknown