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Most people notice a difference in skin radiance and tone after 30 to 60 days of consistent supplementation, as this allows time for new skin cells to cycle to the surface

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Justin Krajeski wrote an earlier version of this article

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This case implies that the melanosis pigment-laden macrophages formed in the lamina propria of the colon pass to the regional lymph nodes and may explain the observation of similar pigment-laden macrophages in other sites